Karlowicze is mentioned in 1554 as a courtyard belonging to the Kiezgajl family, from 1558 to the Vilna chapter. In 1558 in the invetar of the Borodino parish Karlowicze is mentioned: “land … of that Lithuanian village”, from which they gave ‘three buckets of honey and all other payments’. In 1588 there were 3 houses in the village, which paid a tax of 3 kapa and 1 grosz Lithuanian.

According to local legend, two men named Zinowij and Protas were exiled to the local swamps for some offense. The men settled on an island in the swamp, took root here and gave birth to the Zinowicze and Protasewicze surnames. These two surnames are still the most common in the village. Only in the post-war years, when teachers and other specialists were sent to work in the village, ethnic diversity was introduced here.

In written sources it was mentioned in 1793 as a part of Chomsk county, Kobryn district, Brest voivodeship. There were 22 households and 137 inhabitants. From 1795 in the Russian Empire, in Kobryn district, Slonim district, from 1797 in Lithuanian, from 1801 in Grodno province. The village is marked on Szubert’s map of 1826-1840: It is also marked on the military topographic map of the Russian Empire for 1846-1863: In 1858 the village was the center of the rural community in Chomsy parish, Kobrin district, Grodno province, part of the Chomsk estate of the Puslowski.