Osipowicze is mentioned in 1546, in the description of the borders between the Grand Duchy of Lithuania and the Crown of Poland. It was a village in Kobryn district, the property of “Pan Andrei the Doctor”.
In 1783 it was included in Holowczyce key, Brest district.
In 1791 in Kobryn district, from 1795 in the Russian Empire, from 1797 in Lithuanian, and from 1801 in Grodno province.
In 1858, the village was the center of the Osipowicze rural community in Antopol volost. It had 399 “souls” (state villagers).
On Schubert's 1870 map:
According to the Central Statistical Committee (1880–1886), Osipowicze was a former state village with 44 yards and 559 inhabitants, and a drinking house.
In 1905 the village had 929 inhabitants, and there was a parochial school.
From 1921 to 1939, the village was part of Antopol gmina, Kobryn county, Poleskie voivodeship, Poland.
On the WIG map:
From 04.12.1939 the village was in the BSSR. From 1940 it was part of Antopol district and became the center of the village council. In 1940 the population was 833 inhabitants.
On the RKKA map:
During the Great Patriotic War, 53 inhabitants died, including 45 at the front.
Since 1959, the village has been part of Drohiczyn district. In 1960 it had 573 inhabitants, in 1970 — 680. It was the center of the collective farm named after “Karl Marx”. In 1995 there were 205 households and 525 inhabitants.
In the village are preserved:
The mass grave and monument to those who died during the Great Patriotic War:
World War I cemetery:
