Osipowicze is mentioned in 1546, in the description of the borders between the Grand Duchy of Lithuania and the Crown of Poland. It was a village in Kobryn district, the property of “Pan Andrei the Doctor”. In 1783 it was included in Holowczyce key, Brest district. In 1791 in Kobryn district, from 1795 in Russian Empire, Kobryn district, Slonim province, from 1797 in Lithuanian, from 1801 in Grodno province. In 1858, the village Osipowicze in Antopol volost, Kobryn district, the center of the village community.