In the 15th century, Perkowicze belonged to the Turów family. Later, it belonged to the Wojtkowicz family, which was confirmed, among others, by King Sigismund the Old in a privilege granted to Matwiej Wojtkowicz in 1538. The village is mentioned at the end of the 15th and in the first half of the 16th century as part of the Zditowo volost, Troki Voivodeship, Grand Duchy of Lithuania. In 1494, it is mentioned in a letter from Grand Duke Aleksander of Lithuania, which confirms the rights of the Andrejewicz family to own their estates in the Pinsk Principality.

The list of Christian Catholic settlements from 1726 mentions Perkowicze. It is likely that there was already a Uniate church at that time. The present stone church was built around 1770 by Zenon Wislouch, a sub-commodore of Brest, owner of Perkowicze. The construction was completed and decorated by his son Victor in 1805. Originally built in the forms of classicism, the church functioned as a Uniate church. There are also records of priests who served in Perkovichi: